Abstract: Polyethylene glycol(PEG) brush can form a highly hydrophilic layer on the material surfaces to prevent the non-selective adsorption of proteins and reduce the adhesion of bacterium and microbes for its repulsive penetration.The anti-fouling applications of poly(ethylene glycol) brush on polymers,siliceous materials and metal surfaces are reviewed and the possible application on metal surface for anticorrosion is covered.