Abstract: Solid Buoyancy Materials with different ratio of hollow glass microspheres was synthesized by molded forming, with epoxy resin E-4221 as bulk material, dodeceny succinic anhydride and methyl tetrahydrophthalic anhydride as the curing agent, two kinds of hollow glass microspheres named K20 and HGS8000X as lightweight filler. The influence of the ratio of glass microspheres on density, the compressive strength, water absorption and resistance to hydrostatic pressure of solid buoyancy material was studied. The results showed that the introduction of microspheres with lower density could reduce the density of solid buoyancy material effectively. Filling with mixed microspheres was more conducive to reduce the density of solid buoyancy material. High-performance solid buoyancy materials which could be used in different depths was obtained by using mixed microspheres.