Abstract: Acrylate copolymer containing quaternary ammonium salt polymer (QASP) of glycidyl methacrylate-methacryloyloxyethyl trimethyl ammonium chloride-ethyl acrylate has been synthesized by solution polymerization,and the antifouling coatings are prepared by milling the blend of the acrylate copolymer containing QASP with the fumed silica thixotropic agent and cuprous oxide antifouling agent.The test results show that with the increase of DMC amount,the elongation strength of the coating increases first and then decreases,the shear strength increases,and the hydrophilicity becomes better,which is beneficial for protein adsorption resistance;the thermosensitivity becomes intenser;the release rate of Cu²⁺ can stay high even after falling from the peak,which is effective for the antifouling.