Abstract: Pretreatment, forging, rolling and heat treatment for Nb10Zr ingot and the preparation process of Nb10Zr target were investigated. Experiment results showed that when the ingot was pretreated at 1 450 ℃ for 90 min, its plasticity would be improved; circular forging at 1 300 ℃, rolling at 1 000 ℃ and heat treatment at 1 200~1 450 ℃ could prevent the material from cracking in the process of forging and rolling. The grain size of Nb10Zr target was of 8 grade, and the microstructure was uniform.