Abstract: The plastic deformation processing by conventional forging and reversing upsetting and stretching forging was carried out on Ti-6Al-4V alloys, and then the alloys underwent the multi fire reversing hot rolling, the transformation of microstructures of Ti-6Al-4V alloy during which processes were investigated. The results showed that by upsetting and stretching forging and multi fire rolling, the microstructure of the plate evolved from the original slab duplex microstructure (equiaxed α and transformed (α + β)) into a fully equiaxed α morphology gradually, and microstructure was finer and more uniform, ensuring the isotropy of the microstructure and good properties of the plate.