Abstract: Soluble poly (aniline-o-2- (2-aminophenyl) -1, 1, 1, 3, 3, 3-hexafluoropropan-2-ol) (PAH) was prepared from aniline and 2- (2-aminophenyl) -1, 1, 1, 3, 3, 3-hexafluoropropan-2-ol (HAFIP) by chemical oxidation polymerization with ammonium persulphate as initiator. Fourier transform infrared spectroscopy (FTIR), ¹⁹F nuclear magnetic resonance spectroscopy (¹⁹F NMR), 1 H nuclear magnetic resonance spectroscopy (¹H-NMR), Gel permeation chromatography (GPC), ultraviolet spectroscopy (UV) and field emission scanning electron microscopy (FESEM) were used to characterize the chemical structure and morphology of the copolymer. FTIR and NMR results confirm that 2- (2-aminophenyl) -1, 1, 1, 3, 3, 3-hexafluoropropan-2-ol (HAFIP) is successfully introduced to the main chain of the copolymer. GPC results suggest that the number average molecular weight (Mn) of the copolymer is between 6. 51 × 10⁴ and 9. 04 × 10⁴. UV indicates that the presence of HAFIP has inhibited the transition of quinone structure n → π* and SEM reveals that the morphology of the copolymer is changing gradually from nanofibers to nanoparticles with the increase of mole fraction HAFIP of in copolymer. Different from polyaniline, the copolymers with HAFIP molar fraction higher than 0. 5 are completely soluble in organic solvents such as tetrahydrofuran, ethanol, N-methylpyrrolidone, N, N-dimethylformamide, which suggests that the introducing of HAFIP can greatly improve the solubility of polyaniline and thus widen its application field.