导电聚合物聚羟甲基EDOT抗免疫细胞粘附、增殖及活化性能研究

Depressed Attachment, Proliferation and Activation of Immune Cells on Poly(hydroxymethyl EDOT)

摘要: 聚羟甲基EDOT (PEDOT-OH)具有良好的电化学性能,能进行多样化学改性,是一种优秀的有机电极材料。使用小鼠成纤维细胞(NIH 3T3)评价PEDOT-OH的生物相容性,然后以大鼠永生化小神经胶质细胞(HAPI)和大鼠原代巨噬细胞(RM)为免疫细胞模型,研究PEDOT-OH对HAPI细胞和RM细胞的粘附、增殖和活化的影响。结果表明,与聚苯乙烯(细胞培养孔板材料)相比,PEDOT-OH具有更好的生物相容性,对HAPI细胞和RM细胞的粘附、增殖和活化具有显著的抑制作用。

Abstract: Poly (hydroxymethyl EDOT) (PEDOT-OH) has been widely used as an electrode material for bioelectronics due to its excellent electrochemical performance and easy accessibility to chemical modification. In this work, the biocompatibility of PEDOT-OH by culturing NIH3T3 cells on it was evaluated. Effects of PEDOT-OH on the depressed attachment, proliferation and activation of two immune cells, the immortalized rat microglial cells (HAPI) and rat primary macrophage (RM), were investigated. The results indicate that compared with polystgrene, PEDOT-OH has depressed significantly the attachment, proliferation and activation of HAPI cells and RM cells.