Abstract: The influences of Fe content (between 0.04% and 0.41%, w) on microstructures and properties of Ti80 titanium alloy have been studied. The results show that the increase of Fe content can improve the tensile strength at room temperature of Ti80 titanium alloy. The Fe content increases by 0.2%, the tensile strength increases by about 20 MPa. The increase of Fe content has no significant effect on plasticity and impact properties of the alloys. The Fe element can affect the structural morphology of the alloy. When the Fe content increases to 0.41%, the shape of α phase changes from globularity into long strip. During the 30-day test, the addition of Fe element reduces the open circuit potential of Ti80 alloy and results in the increase of average corrosion rates of the alloy under the conditions of natural seawater immersion and the seawater with a flow rate of 5 m/s. The seawater corrosion resistance of the alloy decreases, but still in the same order of magnitude with that of the normal Ti80 alloy.