Abstract: The phase composition, phase morphology and element distribution of TiCu0.5 Al0.5 Cr0.2 Ni0.1 high-entropy alloy are researched by X ray diffraction, optical microscope, scanning electron microscopy(SEM) and transmission electron microscopy(TEM). Its hardness is measured with a vickers microhardness unit at room temperature. The compression tests at room temperature are conducted by an electron universal testing machine. The anti-corrosion and anti-fouling properties of the alloys are studied in a laboratory simulation environment.Resultsshow that the TiCu_0.5Al_0.5Cr_0.2Ni_0.1 high-entropy alloy is mainly composed of hexagonal crystal system Ti(CuAl)₂ phase. There is a strip structure between the bulk Ti(CuAl)₂ phase, the strip is AlCu2 Ti phase, and between the strips is CuTi2 phase. The content of Al and Cr in dendrite(DR) is higher than those in interdendritic region, the content of Ti in interdendritic(ID) is higher than that in dendrite region, and the distribution of Ni and Cu elements is more uniform. The average microhardness of interdendritic(ID) is 772 HV, higher than that of 690 HV of dendritic(DR), and the compressive strength at room temperature is 1 091 MPa. The alloy has excellent corrosion resistance and certain anti-fouling function, and the uniform corrosion weight loss in artificial seawater at 60℃ is only-0.000 05 g.