Abstract: Aimed at the problem of heat pipe and tube sheet joining of the titanium heat pipe heat exchanger with large internal and external pressure difference, a transition sleeve is put between the heat pipe and tube sheet, and the specific process specification is formulated. Firstly, we adopt the pulse TIG welding to weld the heat pipe and sleeve, then manufacture single heat pipe, and finally use electron beam welding to weld the circumferential butt joint between the sleeve and tube sheet. The sample for the test is prepared according to the optimized process. The appearance, non-destructive, low magnification metallography, pull-off and hydrostatic test are carried out on the welded joint. Results show that all the testing results can meet relevant standards, which provides key technologies for the construction of heat exchanger of high quality titanium heat pipe.