Abstract: The traditional gas atomization method (GA) often produces alloy powders with uneven compositions, which affects the quality and performance of the formed parts. Combining plasma melt spraying technology, mechanical alloying technology can obtain spherical refractory high-entropy alloy powders with composition segregation under the influences of mechanical lapping (plastic deformation)and temperature rise (atomic diffusion), and achieve homogenization of metal powders with insoluble elements. Therefore, GH4169 spherical powders with uniform composition are successfully prepared by using a new dual process of mechanical alloying - lasma melt spraying technology. Tensile tests show that the tensile strength of the tensile sample of GH4169 superalloy prepared by selective laser melting method has reached 1 556 MPa, and that the microstructure of the sample is fine equiaxed crystals, and the organizational structure is dense. This research provides theoretical guidance for manufacturing high temperature alloys and alloy parts with excellent performances.