Abstract: The effects of adding DT4 or SL3 sandwich materials on the microstructure and properties of the TA2/Q235B composite plate are studied based on the actual production line. The mechanical properties and microstructure of the TA2/Q235B clad plate are analyzed through metallography (OM), scanning electron microscope (SEM), energy disperse spectrum (EDS), X-ray diffraction (XRD) and mechanical tests. According to the study, the clad plates containing DT4 interlayer has clean interface, less compound, and uniform TiC, and its shear strength is up to 187.4 MPa. As for the clad plate with SL3 interlayer, there is more slag inclusion in the interface, where TiFe, TiNi and other compounds can be found, and the shear strength is only 148.6 MPa. The shear fracture locations of the composite plates of the two sandwiches occur on the titanium side, and the brittle fracture features are found in the fracture. The results show that the shear strength of the DT4 sandwich clad plate is higher, which is conducive to the industrial production.