Abstract: At present, high pressure and large volume carbon fiber fully wound gas cylinders above 450 L (hereinafter referred to as type III gas cylinders) are still in the research stage in China, and there is no current national standard. We carry out the design research of the 45 MPa and 500 L type III gas cylinder. According to the grid theory, the safety design of carbon fiber winding layer should be done under blasting pressure. It is analyzed the stress of aluminum liner and winding layer under the working condition of the high pressure large volume type III gas cylinder. And the liner design of this type of gas cylinder is completed on the premise of ensuring that the joint surface doesn't fail. Under the limit pressure of blasting of the type III gas cylinder, the winding shell can be regarded as an orthotropic thin-walled shell structure. When the internal strain displacement relationship of the shell is same, we check and calculate the strength of the liner to ensure its safety.