Abstract: Titanium alloy flat ingots are prepared by using a short process, low-cost EB melting method, and then rolled directly without forging to prepare a 700 MPa grade 20 mm thick Ti-Al-Mo-V-Zr-Sn system titanium alloy hot rolled plate. The effect of heat treatment process on the microstructure and properties of the titanium alloy plate is studied. The results show that the Ti-Al-Mo-V-Zr-Sn titanium alloy flat ingots with uniform composition can be obtained through one-time EB melting. The medium strength and high toughness titanium alloy plates can be obtained by rolling at the temperature near the T_β transus, and reversing rolling the α+β zone and annealing the finished product at the temperature below the T_β transus. With the increase of heat treatment temperature, the impact toughness of titanium alloy plates is improved. The match between strength and toughness is good when the heat treatment temperature is near the T_β transus and above 900 ℃.